The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes

@article{Wyss1998ThePO,
  title={The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes},
  author={Pius Wyss and Alain Stricker-Krongrad and L Brunner and JAMESA. MILLER and Leoluca Criscione},
  journal={Regulatory Peptides},
  year={1998},
  volume={75–76},
  pages={363-371}
}
Thirteen neuropeptide Y (NPY) agonists were administered intracerebroventricularly (i.c.v.) in rats (full dose-response curves) to estimate their half-effective dose (ED50) on feeding. These values were compared to their binding affinities (IC50) for rat NPY receptor subtypes Y1, Y2, Y4 and Y5 in vitro. Correlations between in vivo ED50 and in vitro IC50 were strong for the Y5 (r = 0.87; P < 0.01), weak for the Y1 (r = 0.48; P < 0.04) and non-significant for the Y2 and Y4 receptor subtypes. In… CONTINUE READING

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Neuropeptide Y in normal eating and in genetic and dietary-induced obesity.

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