The pharmacology of mechanogated membrane ion channels.

  title={The pharmacology of mechanogated membrane ion channels.},
  author={Owen P. Hamill and Don W. McBride},
  journal={Pharmacological reviews},
  volume={48 2},
In this article, the actions, mechanisms and applications of various ions and drugs that interact with MG channels have been discussed. At present, no compound has been found that displays the high specificity and affinity exhibited by tetrodotoxin or alpha-bungarotoxin that proved so useful in the functional and structural characterization of the voltage-gated Na+ channel and the acetylcholine receptor channel, respectively. Nevertheless, three different classes of compounds have been… CONTINUE READING


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