The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy.

@article{Rundfeldt2014ThePO,
  title={The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy.},
  author={Chris Rundfeldt and Wolfgang L{\"o}scher},
  journal={CNS drugs},
  year={2014},
  volume={28 1},
  pages={29-43}
}
Although benzodiazepines (BZDs) offer a wide spectrum of antiepileptic activity against diverse types of epileptic seizures, their use in the treatment of epilepsy is limited because of adverse effects, loss of efficacy (tolerance), and development of physical and psychological dependence. BZDs act as positive allosteric modulators of the inhibitory neurotransmitter GABA by binding to the BZD recognition site ("BZD receptor") of the GABAA receptor. Traditional BZDs such as diazepam or… CONTINUE READING

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