The pharmacology of ebselen

  title={The pharmacology of ebselen},
  author={Michael J. Parnham and Sigurd Dr. Leyck and Erich Dr. Graf and E. J. Dowling and David R. Blake},
  journal={Agents and Actions},
ConclusionEbselen has been demonstrated to be an effective anti-inflammatory agent in a variety of experimental modelsin vivo which differ from classical tests in that the aetiological roles of hydroperoxides and/or lipoxygenase products appear to be greater. Indeed, ebselen exhibits only weak anti-inflammatory activity in the traditional prostaglandin-dominated models, such as carrageenan paw oedema, adjuvant arthritis and yeast paw hyperalgesia [50]. The major targets of this anti… 

Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections

Toxicology and pharmacology of synthetic organoselenium compounds: an update

The outcomes of the clinical trials of ebselen as a mimetic of lithium or as an inhibitor of SARS-CoV-2 proteases will be important to the field of organoselenium synthesis.

Comparison of the Effects of Topical Ebselen, Propolis and Steroid Applications on Acute Radiodermatitis: Preliminary Results

Data obtained in this study suggest that combined use of MF, propolis and ebselen according to erythema phases may mitigate the clinical progression of acute radiodermatitis.

Drug Antioxidant Effects

The therapeutic efficacy of SOD, α- tocopherol and ascorbic acid in the treatment of human disease is generally unimpressive to date although dietary deficiencies of the last two molecules should certainly be avoided.

Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications

  • M. Parnham
  • Medicine, Biology
    Inflammation Research
  • 2016
Fine tuning of experimental approaches and evaluation technologies can often still provide innovative, clinically relevant insights into the potential beneficial effects of drugs and pharmacological agents.

Experimental and clinical evidence of antioxidant therapy in acute pancreatitis.

The use of antioxidant enriched nutrition is a potential direction of clinical research in AP given the lack of clues about the efficiency and safety of antioxidant usage in patients with AP.

Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines

Ebselen treatment of pancreatic and renal cancer cell lines stalled tumor growth and inhibited invasion through Matrigel in vitro and the results here offer a “proof-of-principle” that enzymatic inhibition of QSOX1 may have clinical relevancy.

Organoselenium and organotellurium compounds: toxicology and pharmacology.

The structure-activity relationship for a given class of organoselenium or organotellurium compounds should be used as a toll for screening molecules with high probability of exhibiting low toxicity and high pharmacological activity in mammals.



The anti-inflammatory activity of Ebselen but not thiols in experimental alveolitis and bronchiolitis

The finding that in Ebselen-only treated animals there was a selective inhibition of the infiltration of lymphocytes, basophils and eosinophils into the lung lumen without affecting the populations of macrophages and neutrophils, and the Ebselsen-induced effect was reduced by coadministration of either thiol.

Structure-activity relationships of a series of anti-inflammatory benzisoselenazolones (BISAs)

A series of benzisoselenazolones (BISAs) and their respective benzisothiazolones in in vitro and in vivo tests are tested in an attempt to increase the potency in comparison to ebselen.

Rosmarinic acid: a new inhibitor of complement C3-convertase with anti-inflammatory activity.

Free radicals and anti-inflammatory drugs.

In addition to the earlier described inhibition of formation of prostanoids, non-steroidal anti-inflammatory drugs can inhibit production of free radicals or scavenge those already formed, which are beneficial in killing bacteria.

Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.

It is demonstrated that ebselen is a potent cytoprotective agent effectively preventing the gastric mucosal injury induced by necrotizing agents.

Effects of the Seleno‐Organic Substance Ebselen in Two Different Models of Acute Pancreatitis

The selenoorganic compound Ebselen may exert its beneficial effects on survival not only by acting on the primary pancreatic lesion, but it may in addition act on extrapancreatic complications that contribute to mortality in this animal model of hemorrhagic pancreatitis as well as in the human disease.

Leukotriene-mediated liver injury.

Ebselen (PZ-51) Inhibits the Formation of Ischemic Brain Edema

Ebselen is a novel organoselenium compound which catalytically inactivates peroxide in vitro in a manner similar to that of glutathione peroxides and has an inhibitory effect on lipoxygenase and reduces leukotriene B4 formation with a concomitant decrease in 5-HETE production.

Inhibitory effects of ebselen on lipid peroxidation in rat liver microsomes.

It is suggested that ebselen penetrates into the membrane lipid and acts as an effective antioxidant, and that there may be some differences between the modes of inhibitory action on the several types of lipid peroxidation.