The pharmacology of ebselen

@article{Parnham2005ThePO,
  title={The pharmacology of ebselen},
  author={Michael J. Parnham and Sigurd Dr. Leyck and Erich Dr. Graf and E. J. Dowling and David R. Blake},
  journal={Agents and Actions},
  year={2005},
  volume={32},
  pages={4-9}
}
ConclusionEbselen has been demonstrated to be an effective anti-inflammatory agent in a variety of experimental modelsin vivo which differ from classical tests in that the aetiological roles of hydroperoxides and/or lipoxygenase products appear to be greater. Indeed, ebselen exhibits only weak anti-inflammatory activity in the traditional prostaglandin-dominated models, such as carrageenan paw oedema, adjuvant arthritis and yeast paw hyperalgesia [50]. The major targets of this anti… 

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References

SHOWING 1-10 OF 49 REFERENCES

The anti-inflammatory activity of Ebselen but not thiols in experimental alveolitis and bronchiolitis

The finding that in Ebselen-only treated animals there was a selective inhibition of the infiltration of lymphocytes, basophils and eosinophils into the lung lumen without affecting the populations of macrophages and neutrophils, and the Ebselsen-induced effect was reduced by coadministration of either thiol.

Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen

Ebselen represents a new tool for antiinflammatory therapy when compared with indometacin, BW 755C, and levamisole as an inhibitor of carrageenan- and CVF (cobra venom factor)-induced paw oedema in the rat.

Structure-activity relationships of a series of anti-inflammatory benzisoselenazolones (BISAs)

A series of benzisoselenazolones (BISAs) and their respective benzisothiazolones in in vitro and in vivo tests are tested in an attempt to increase the potency in comparison to ebselen.

Rosmarinic acid: a new inhibitor of complement C3-convertase with anti-inflammatory activity.

Free radicals and anti-inflammatory drugs.

In addition to the earlier described inhibition of formation of prostanoids, non-steroidal anti-inflammatory drugs can inhibit production of free radicals or scavenge those already formed, which are beneficial in killing bacteria.

Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.

It is demonstrated that ebselen is a potent cytoprotective agent effectively preventing the gastric mucosal injury induced by necrotizing agents.

Effects of the Seleno‐Organic Substance Ebselen in Two Different Models of Acute Pancreatitis

The selenoorganic compound Ebselen may exert its beneficial effects on survival not only by acting on the primary pancreatic lesion, but it may in addition act on extrapancreatic complications that contribute to mortality in this animal model of hemorrhagic pancreatitis as well as in the human disease.