The pharmacology of cocaethylene in humans following cocaine and ethanol administration.

@article{Harris2003ThePO,
  title={The pharmacology of cocaethylene in humans following cocaine and ethanol administration.},
  author={Debra S. Harris and E. Thomas Everhart and John E. Mendelson and Reese Jones},
  journal={Drug and alcohol dependence},
  year={2003},
  volume={72 2},
  pages={169-82}
}
BACKGROUND Concurrent use of cocaine and alcohol results in formation of a cocaine homolog and metabolite-cocaethylene. METHODS To characterize cocaethylene pharmacology, ten paid volunteer subjects were given deuterium-labeled (d(5)) cocaine (0.3, 0.6, and 1.2 mg/kg and cocaine placebo) by a 15-min constant rate intravenous injection 1 h after a single oral dose of ethanol (1 g/kg) or ethanol and cocaine placebo using a double-blind, crossover design. Six of the same volunteers subsequently… CONTINUE READING

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