The pharmacology of carvedilol
@article{Ruffolo2005ThePO, title={The pharmacology of carvedilol}, author={Robert R. Ruffolo and Miklos Gellai and Jacob Paul Hieble and Robert Nicholas Willette and Andrew J. Nichols}, journal={European Journal of Clinical Pharmacology}, year={2005}, volume={38}, pages={S82-S88} }
SummaryCarvedilol is a potent antihypertensive agent with a dual mechanism of action. At relatively low concentrations it is a competitive β-adrenoceptor antagonist and a vasodilator, whereas at higher concentrations it is also a calcium channel antagonist. The antihypertensive activity of carvedilol is characterized by a decrease in peripheral vascular resistance, resulting from the vasodilator activity of the compound, with no reflex tachycardia, as a result of β-adrenoceptor blockade. The…
178 Citations
Clinical pharmacology of carvedilol
- MedicineThe clinical investigator
- 2004
SummaryAnimal work has shown that carvedilol is a nonselective β-blocking drug. It has a vasodilator action from α-receptor blockade, but there is evidence that it has further action to relax smooth…
Carvedilol and the kidney
- Medicine, BiologyThe clinical investigator
- 2004
It is concluded from these studies that renal perfusion and renal function are well maintained during acute and chronic treatment with carvedilol.
Pharmacological profile of β-adrenoceptor blockers with vasodilating properties, especially carvedilol — rationale for clinical use
- Medicine, BiologyThe clinical investigator
- 2004
Carvedilol is a dual-acting drug designed to produce β-blockade and vasodilatation in the same dose range, designed to reduce the total peripheral resistance, and blood flow to the kidneys is preserved.
Pharmacology of Carvedilol: Rationale for Use in Hypertension, Coronary Artery Disease, and Congestive Heart Failure
- Medicine, BiologyCardiovascular Drugs and Therapy
- 2004
The multiple actions of carvedilol may provide the underlying pharmacologic rationale for the use of this drug in the treatment of patients with coronary artery disease or congestive heart failure, and these actions may account, at least in part, for the reduction in mortality produced by carveilol in clinical trials involving patients with congestiveheart failure.
Electrophysiologic Effects of Carvedilol: Is Carvedilol an Antiarrhythmic Agent?
- Biology, MedicinePacing and clinical electrophysiology : PACE
- 2005
Experimental data available on the electrophysiologic properties of carvedilol are reviewed, with a focus on their clinical relevance.
The dose dependency of the (x- and ,-adrenoceptor antagonist activity of carvedilol in man
- Medicine, Biology
- 2006
In conclusion, carvedilol 6.25, 12.5 and 25 mg demonstrated ,-adrenoceptor antagonist activity with some evidence for a-adRenoceptor antagonists activity with the 25 mg dose, and labetalol 400 mg showed both ,B- and a-Adreno receptor antagonist activity, with a IP- to a- adrenOceptor antagonist ratio of approximately 4 to 1.
Comparison of the antihypertensive effects of carvedilol and metoprolol on resting and exercise blood pressure
- MedicineThe clinical investigator
- 2004
Carvedilol was even effective in the treatment of patients whose blood pressure was unsatisfactorily controlled by metoprolol, showing the importance of the vasodilation component of carvedilol.
Controlled-release carvedilol in the treatment of essential hypertension.
- MedicineThe American journal of cardiology
- 2006
β-Adrenoceptor Blocker Carvedilol Provides Cardioprotection via an Adenosine-Dependent Mechanism in Ischemic Canine Hearts
- Medicine, BiologyCirculation
- 2004
Carvedilol shows a cardioprotective effect against ischemia and/or reperfusion injury via adenosine-dependent mechanisms in dogs and in human umbilical vein endothelial cells cultured with or without xanthine andxanthine oxidase, carvedilol caused an increase of ecto-5′-nucleotidase activity.
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