The pharmacology of carvedilol

@article{Ruffolo2005ThePO,
  title={The pharmacology of carvedilol},
  author={R. Ruffolo and M. Gellai and J. Hieble and R. Willette and A. J. Nichols},
  journal={European Journal of Clinical Pharmacology},
  year={2005},
  volume={38},
  pages={S82-S88}
}
SummaryCarvedilol is a potent antihypertensive agent with a dual mechanism of action. At relatively low concentrations it is a competitive β-adrenoceptor antagonist and a vasodilator, whereas at higher concentrations it is also a calcium channel antagonist. The antihypertensive activity of carvedilol is characterized by a decrease in peripheral vascular resistance, resulting from the vasodilator activity of the compound, with no reflex tachycardia, as a result of β-adrenoceptor blockade. The… Expand
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