The pharmacology of beta-adrenergic blocking agents.

@article{Lucchesi1969ThePO,
  title={The pharmacology of beta-adrenergic blocking agents.},
  author={Benedict Robert Lucchesi and L S Whitsitt},
  journal={Progress in cardiovascular diseases},
  year={1969},
  volume={11 5},
  pages={
          410-30
        }
}
Pharmacology of Clinically Useful Beta-Adrenergic Blocking Drugs
The adrenergic receptor has been known for sixty years. Sir Henry Dale named it the receptive mechanism for adrenaline. Since the time of Cannon the existence of at least two kinds of adrenergic
Effect of Adrenergic Activators and Inhibitors on the Electrical Activity of the Heart
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It is stated that the endogeneous catecholamines liberated by sympathetic excitation may substantially affect those electrophysiologic parameters of the heart which have been shown to play a significant role in the regulation of cardiac rate and rhythm and in the genesis of cardiac arrhythmias.
Comparative chronotropic activity of beta-adrenoceptive antagonists.
TLDR
Estimation of beta-adrenoceptor blocking activity in anaesthetized cats gave an order of activity dissimilar to that found for maximum agonist responses, which did not explain the differences between the agonist activities of the adrenoceptive antagonists.
Effects of beta-adrenoceptor blocking agents on haemodynamic parameters.
  • L. Hansson
  • Medicine
    Acta medica Scandinavica. Supplementum
  • 1977
TLDR
The topic of combined treatment of hypertension using a beta-adrenoceptor-blocking agent in conjunction with a vasodilator and the haemodynamic effects thereof is briefly discussed, and finally some data are presented on the effect of beta- adrenocept-blockade on regional haemodynamics.
Effect of β‐adrenoceptor blocking agents on poststimulatory atrial flutter in the dog, with observations on the participation of adrenergic mechanisms in this experimental arrhythmia
TLDR
Flutter could not be produced in nine out of ten dogs whose catecholamine stores were depleted by pretreatment with reserpine, and infusion of adrenaline in these animals resulted in the production of flutter.
The Clinical Relevance of Beta-Receptor Blockade, Intrinsic Sympathomimetic Activity and Membrane Depressant Action
TLDR
In this chapter, the relevance of some of these factors in clinical therapy with the β-adrenoreceptor blocking drugs will be reviewed.
Mechanism of Epinephrine and Serotonin Inhibition of Insulin Release in the Golden Hamster in Vitro
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The data indicate that both amines block insulin release by interfering with the action of 3′5′ cyclic AMP in causing insulin release.
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Because “adrenergic receptors” are often mentioned in discussions of drugs which affect adrenergic mechanisms, it is useful to consider some general aspects of drug-receptor interaction. Relatively
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