Corpus ID: 36950795

The pharmacology of benoxaprofen with particular to effects on lipoxygenase product formation.

  title={The pharmacology of benoxaprofen with particular to effects on lipoxygenase product formation.},
  author={William Dawson and John R. Boot and J Harvey and J. R. L. Walker},
  journal={European journal of rheumatology and inflammation},
  volume={5 2},
Benoxaprofen has three pharmacological activities which may relate to its clinical activity profile. The most important of these for anti-inflammatory therapy is the regulation of directional monocyte movement in response to a stimulus but the inhibitory activity against lipoxygenase may be of considerable relevance in the treatment of asthma. The relatively weak inhibitory action on prostaglandin synthetase probably confers clinical benefit with a reduced potential to cause severe gastric side… Expand
Effects of non-steroidal anti-inflammatory drugs on polymorphonuclear leukocyte functions in vitro: focus on fenamates
It is concluded that NSAIDs with a fenamate structure differ from other NSAIDs by inhibiting PMN functions induced either by receptor-mediated stimulus (LTB4) or calcium ionophore (A23187) at micromolar drug concentrations. Expand
Ketoprofen-Induced Cyclooxygenase Inhibition in Renal Medulla and Platelets of Rats Treated with Caffeine
Keatonrofen caused inhibition of PGE2 biosynthesis in the rat renal medulla ex vivo with a potency similar to that reported for in vivo models suggesting that the ex vivo approach is a valid model to test a possible interference of caffeine with ketoprofen-induced COX inhibition. Expand
Carboranyl Analogues of Ketoprofen with Cytostatic Activity against Human Melanoma and Colon Cancer Cell Lines
The synthesis and evaluation of four novel carborane-containing derivatives of ketoprofen are reported, two of which are prodrug esters with an nitric oxide-releasing moiety that exhibited high cytostatic activity against melanoma and colon cancer cell lines. Expand
Prostaglandins and the gastrointestinal mucosa: are they important in its function, disease, or treatment?
The involvement of prostaglandins and related compounds in mucosal protection, in ulcer healing, in diarrhea, and in gastrointestinal inflammation is reviewed, with particular reference to the growing body of human data. Expand
  • B. Allen
  • Medicine
  • The British journal of dermatology
  • 1983
Benoxaprofen [2-chlorophenyl)-a-methyl-5-benzoxazole acetic acid] is a propionic acid derivative with anti-inflammatory properties which was marketed in the U.K. between May 1980 and August 1982 and surrendered by the manufacturers in August 1982. Expand
Non-steroidal anti-inflammatory drugs
This is a group of drugs with analgesic, antipyretic and anti-inflammatory properties whose main role is to provide symptomatic relief of pain and stiffness in various rheumatic and other conditions.Expand
Benoxaprofen in the treatment of active ulcerative colitis.
Benoxaprofen itself seems unlikely to prove useful in ulcerative colitis, but evaluation of the therapeutic potential of other lipoxygenase inhibitors in inflammatory bowel disease may be worthwhile. Expand
Effects of two different inhibitors of the arachidonic acid metabolism on platelet sequestration in endotoxic shock
  • G. Sigurdsson, H. Youssef, Azu Owunnwanne
  • Chemistry, Medicine
  • Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
  • 1994
It is concluded that the dual cyclo oxygengenase and lipoxygenase inhibitor ketoprofen offered significantly more effective protection against endotoxin-induced platelet sequestration in the lungs and the liver than the cyclooxygen enzyme inhibitor aspirin. Expand
Advances in anti-inflammatory therapy.
Compounds are being developed which act selectively to block the formation or actions of these mediators and the potential of such agents as anti-inflammatory drugs is discussed, although such compounds do not, at present, have veterinary applications. Expand
Prostaglandins, Leukotrienes, Related Compounds and Their Inhibitors
KURZROK and LIEB (1930) found that fresh human semen induced either strong relaxation or strong contraction of the human uterus. Several years later, two independent workers, GOLDBLATT (1935) and VONExpand