The pharmacology of Limulus central neurons.

@article{Walker1982ThePO,
  title={The pharmacology of Limulus central neurons.},
  author={Robert J. Walker and Christopher J. Roberts},
  journal={Comparative biochemistry and physiology. C: Comparative pharmacology},
  year={1982},
  volume={72 2},
  pages={
          391-401
        }
}
  • R. Walker, C. Roberts
  • Published 1982
  • Biology, Medicine
  • Comparative biochemistry and physiology. C: Comparative pharmacology
1. Intracellular recordings have been made from neurons in the central nervous system of the horse-shoe crab, Limulus polyphemus. Neurons possess resting potentials between -40 and -60 mV, with action potentials ranging from 2-3 mV up to 60 mV in amplitude. Neurons also have excitatory and inhibitory postsynaptic potentials. 2. All the neurons studied are inhibited by GABA and excited by cholinomimetics. The GABA response is chloride mediated and reversibly antagonised by picrotoxinin but not… Expand
Neuropharmacological studies on the receptors mediating responses to carbachol, amino acids and octopamine on Limulus and Hirudo central neurons.
  • R. Walker, C. Roberts
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Intracellular recordings have been made from neurons in the nerve cord of the horse-shoe crab, Limulus polyphemus, with noradrenaline being about 100 times less potent than dopamine, and the pharmacology of these neurons is compared to insect and crustacean central neurons. Expand
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Intracellular recordings were made from neurons in the abdominal ganglia of Limulus polyphemus and p -tolyl silatrane had no blocking action on the GABA inhibitory responses of these neurons. Expand
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Interaction between light-evoked, natural synaptic transmitter-mediated IPSP's and 5-HTIPSP's suggests a common postsynaptic receptor or transmitter-receptor-permeability change mechanism. Expand
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