The pharmacology and neural circuitry of sensitization to psychostimulants.

  title={The pharmacology and neural circuitry of sensitization to psychostimulants.},
  author={P W Kalivas and B Sorg and M. Stacy Hooks},
  journal={Behavioural pharmacology},
  volume={4 4},
Behavioral sensitization to amphetamine-like psychostimulants is manifest as a progressive increase in drug-induced anxiety and paranoia which can culminate in psychopathologies, such as paranoid psychosis and panic attacks. Sensitization may also mediate the facilitation of drug relapse in addicts by increasing the reinforcing value of acute drug administration. The primary animal model for psychostimulant-induced psychopathologies involves repeated, non-contingent administration of drug to… CONTINUE READING
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