The pharmacology and metabolism of testosterone undecanoate (TU), a new orally active androgen.

@article{Coert1975ThePA,
  title={The pharmacology and metabolism of testosterone undecanoate (TU), a new orally active androgen.},
  author={A. Coert and Joyce M. Geelen and J J de Visser and J van der Vies},
  journal={Acta endocrinologica},
  year={1975},
  volume={79 4},
  pages={789-800}
}
Testosterone undecanoate (TU), either dissolved in arachis oil or as micro-crystal suspension, displays androgenic activity on oral administration to rats in the Hershberger test. The solution in arachis oil is more active than the crystal suspension. When [3H]TU is administered orally to rats, most of it is metabolized in the intestinal wall. The majority of the metabolites probably lose their undecanoate group and are absorbed via the portal vein. The non-metabolized [3H]TU and at least two… CONTINUE READING

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