The pharmacological properties of the presynaptic serotonin autoreceptor in the pig brain cortex conform to the 5-HT1D receptor subtype

@article{Schlicker2004ThePP,
  title={The pharmacological properties of the presynaptic serotonin autoreceptor in the pig brain cortex conform to the 5-HT1D receptor subtype},
  author={E Schlicker and Klaus B. Fink and Manfred Göthert and Daniel Hoyer and Gerhard J. Molderings and I. Roschke and Philippe Schoeffter},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={340},
  pages={45-51}
}
SummaryThe effects of serotonin receptor agonists and antagonists on the electrically (3 Hz) evoked 3H overflow were determined on pig brain cortex slices preincubated with 3H-serotonin and superfused with physiological salt solution containing indalpine (an inhibitor of serotonin uptake) plus phentolamine. The potencies of the serotonin receptor agonists and antagonists were compared with their affinities for 5-HT1A, 5-HT1B, 5-HT1c, and 5-HT1D binding sites in pig or rat tissue membranes; in… 
Metitepine distinguishes two receptors mediating inhibition of [3H]-5-hydroxytryptamine release in guinea pig hippocampus
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Heterogeneity in the receptor mediating inhibition of [3H]-5-HT release in guinea pig hippocampus is suggested, as well as the ability of metitepine to antagonise the effects of sumatriptan or 5-CT in this model.
Effects of 5-HT4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus
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5-methoxytryptamine may both inhibit (via 5-HT1 receptors) and facilitate (via5-HT4 receptors) the evoked release of acetylcholine from guinea-pig myenteric neurones and the facilitatory action is unmasked when the 5- HT1 receptor is blocked by methiothepine.
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Serotonin receptors in the brain of rats treated chronically with imipramine or RU24969: support for the 5-HT1B receptor being a 5-HT autoreceptor.
TLDR
The results correspond to what could be expected, if the 5-HT1B receptor is the 4-HT autoreceptor, and the density of 5- HT2 receptors increased and decreased after treatment with RU24969 and imipramine, compared with control rats.
In vitro and in vivo activity of 1-(1-naphthyl)piperazine at terminal 5-HT autoreceptors in guinea-pig brain
  • C. Moret, M. Briley
  • Biology, Chemistry
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
TLDR
In vitro results suggest that in vitro NP acts as a 5-HT autoreceptor partial (ant)agonist in the substantia nigra and hypothalamus of guinea-pigs, and as a full antagonist in vivo, however, in vivo NP administered systemically at 10 mg/kg i.p., did not modify the levels of extracellular 5- HT in the substantive nigra.
5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells
TLDR
This is the first report of a cell line expressing endogenous, well-characterized, 5-HT1D receptors inhibiting cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells.
5-HT1-like receptor mediated changes in porcine carotid haemodynamics: are 5-HT1D receptors involved?
TLDR
It is concluded that neither the constrictor nor the dilator carotid 5-HT1-like receptors seem to be related to the known 5-ht1 binding subtypes, including the 5- HT1D subtype.
How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors
TLDR
The present data show that GR 43175 interacts preferentially as an agonist with 5- HT1B and 5-HT1D receptors, and it seems possible that it is the 5-ht1D receptor which is relevant to the reported antimigraine effects of this compound.
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TLDR
In rat brain cortex slices preincubated with [3H]5-HT, the evidence indicates that the presynaptic 5- HT autoreceptor belongs to the 5-HT1B receptor subtype.
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