The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice.

Abstract

Two major classes of plasma membrane proteins that actively extrude a wide range of structurally diverse hydrophobic amphipathic antineoplastic agents from cells, with different mechanisms of action, lead to multidrug resistance. To study the importance of these ATP-binding cassette transporters to the toxicity of cancer chemotherapy agents, we have used… (More)

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