The pharmacological management of dental pain

  title={The pharmacological management of dental pain},
  author={Joseph V. Pergolizzi and Peter Magnusson and Jo Ann LeQuang and Christopher G. Gharibo and Giustino Varrassi},
  journal={Expert Opinion on Pharmacotherapy},
  pages={591 - 601}
ABSTRACT Introduction Dental pain is primarily treated by dentists and emergency medicine clinicians and may occur because of insult to the tooth or oral surgery. The dental impaction pain model (DIPM) has been widely used in clinical studies of analgesic agents and is generalizable to many other forms of pain. Areas Covered The authors discuss the DIPM, which has allowed for important head-to-head studies of analgesic agents, such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs… 
Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain?
The ideal analgesic has yet to be developed, but effective pain control pharmacological regimens for acute pain are available and combination therapy or nonopioid therapy may be preferred.
Efficacy of ibuprofen gargle for postoperative pain after mandibular third molar extraction: a phase II, placebo-controlled, double-blind, randomized crossover trial (Preprint)
BACKGROUND Extraction of mandibular third molars is one of the most commonly performed oral surgical procedures, and non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain
A meta-analysis on the efficacy of the ropivacaine infiltration in comparison with other dental anesthetics.
Data of this study indicate that ropivacaine infiltration produces a longer anesthetic time when compared with lidocaine and articaine but not when compared to bupvacaine in dental procedures.
E cacy of Ibuprofen Gargle for Postoperative Pain After Mandibular Third Molar Extraction: A Phase II, Placebo-Controlled, Double-Blind, Randomized Crossover Trial
Yasumasa Kakei (  ) Kobe University Graduate School of Medicine School of Medicine: Kobe Daigaku Daigakuin Igakukei Kenkyuka Igakubu


Analgesic agents and strategies in the dental pain model.
As a clinical research tool the dental pain model has several attributes which suggest that it will continue to be of value in identifying potentially improved analgesic strategies for postoperative pain.
Diagnosis and treatment of abnormal dental pain
  • K. Fukuda
  • Medicine
    Journal of dental anesthesia and pain medicine
  • 2016
In this clinical review, a case of referred pain from the digastric muscle, of pulpectomized (Patients 1, 2, and 3) is presented to illustrate referred, neuromodulatory, and neuropathic pain, respectively.
Neuropathic pain after dental treatment.
  • Neslihan Tinastepe, K. Oral
  • Medicine
    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology
  • 2013
In this review, only post-traumatic peripheral pain neuropathies seen after dental treatments will be discussed.
The value of the dental impaction pain model in drug development.
The modern version of the Dental Impaction Pain Model (DIPM) was developed in the mid-1970s and is arguably the most utilized of all the acute pain models due to the success rate of the studies, fast subject entry, and cost effectiveness.
Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice.
The results of the quantitative systematic reviews indicated that the ibuprofen-APAP combination may be a more effective analgesic, with fewer untoward effects, than are many of the currently available opioid-containing formulations.
Benefits and harms associated with analgesic medications used in the management of acute dental pain: An overview of systematic reviews.
The best available data suggested that the use of nonsteroidal medications, with or without acetaminophen, offered the most favorable balance between benefits and harms, optimizing efficacy while minimizing acute adverse events.
Single Dose Analgesic Efficacy of Tapentadol in Postsurgical Dental Pain: The Results of a Randomized, Double-Blind, Placebo-Controlled Study
Single oral doses of tapentadol 75 mg or higher effectively reduced moderate-to-severe postoperative dental pain in a dose-related fashion and were well-tolerated relative to morphine, suggesting that tapentdol is a highly effective, centrally acting analgesic with a favorable side effect profile and rapid onset of action.
Transdermal diclofenac patches for control of post-extraction pain. Pilot randomized controlled double-blind study
Transdermal route seems to be comparable to oral diclofenac in post-extraction pain relief; further studies are required to confirm the results and safety for its use in various other dental situations.
Opioid Prescribing After Surgical Extraction of Teeth in Medicaid Patients, 2000-2010.
Little information is available on nationwide patterns of opioid prescribing following tooth extraction, and surveys suggest that dental practitioners commonly prescribe opioids following this procedure, despite evidence that a combination of nonsteroidal medications and acetaminophen may provide more effective analgesia for postextraction pain.
Longer analgesic effect with naproxen sodium than ibuprofen in post-surgical dental pain: a randomized, double-blind, placebo-controlled, single-dose trial
The duration of pain relief after a single dose of NAPSO was significantly longer than after IBU, and significantly fewer NAPso-treated subjects required rescue medication over a 24-h period.