The pharmacological effects of Salvia species on the central nervous system

  title={The pharmacological effects of Salvia species on the central nervous system},
  author={Mohsen Imanshahidi and Hossein Hosseinzadeh},
  journal={Phytotherapy Research},
Salvia is an important genus consisting of about 900 species in the family Lamiaceae. Some species of Salvia have been cultivated world wide for use in folk medicine and for culinary purposes. The dried root of Salvia miltiorrhiza, for example, has been used extensively for the treatment of coronary and cerebrovascular disease, sleep disorders, hepatitis, hepatocirrhosis, chronic renal failure, dysmenorrhea, amenorrhea, carbuncles and ulcers. S. officinalis, S. leriifolia, S. haematodes, S… 
Recent Studies on the Neuropharmacological Effects of Salvia officinalis L.: A Promising Candidate for Alzheimer's Disease
The neurobiological effects of SO on the central nervous system will be reviewed, including analgesic, memory enhancing, neuroprotective, anticonvulsant, anti-addictive, sedative, anxiolytic, and skeletal muscle relaxant effects.
Salvia spp.: An Updated on Antioxidant Activity and Pharmacological Uses
The aim of this chapter is to update of antioxidant activity and pharmacological uses of species of Salvia to provide a better understanding of their therapeutic application.
Review of the Pharmacological and Toxicological Effects of Salvia leriifolia
In recent years, the different properties of this plant such as the attenuation of morphine dependence, hypoglycemic, antinociceptive and antiinflammatory, antioxidant, antiischemia, anticonvulsant, antiulcer effects, antibacterial activities and antimutagenic effects were evaluated.
Anti-Anxiety Effect of Salvia hypoleuca
This study demonstrated that the hydro-alcoholic and methanol extracts of aerial parts of S. hypoleuca have anti-anxiety activity.
Antinociceptive activity and effect of methanol extract of Salvia limbata on withdrawal syndrome in mice.
The protective effect of S. limbata on the development of dependence to morphine in mice was studied to study the effect of its aerial parts on morphine dependence.
Pharmacological activity of "Salvia lavandulifolia" and chemical components of its essential oil. A Review
The present review summarizes the information concerning the botany, ethnopharmacology, phytochemistry, pharmacological activities and toxicity of the Salvia lavandulifolia plant, because these findings suggest the need for further research of this plant.
Cytotoxic Effects of Salvinorin A, A Major Constituent of Salvia divinorum.
This is the first work focused on the in vitro toxicity of S. divinorum and salvinorin A using a variety of cell lines, which are extensively described in literature and have been widely used in several in vitro studies.
Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice
Investigation of the antidepressant effects of the aqueous and hydroalcoholic extracts of Salvia mirzayanii and Salvia macrosiphon in Iran indicated that these endemic Iranian Salvia species may have potential therapeutic effects for depression.


Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle, Cirsiliol.
Plants and the central nervous system
  • E. Carlini
  • Psychology
    Pharmacology Biochemistry and Behavior
  • 2003
Reducing effect of Salvia miltiorrhiza extracts on alcohol intake: influence of vehicle
The results of the present study demonstrate that Polysorbate 80 is a proper vehicle for unravelling the reducing effect of Salvia miltiorrhiza extracts on alcohol intake, and may offer relevant information for pharmaceutical preparation of Salpsorrhiza extract to be used in future clinical trials.
Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo‐controlled trial
The objective of this study was to assess the efficacy and safety of Salvia officinalis extract using a fixed dose (60 drops/day), in patients with mild to moderate Alzheimer's disease, over a 4‐month period.
Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor.
Three flavones and two abietane diterpenes functioning as benzodiazepine receptor-active components are revealed and the affinities of the newly discovered diterpene receptor ligands, i.