The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer

@article{Hyttel2005ThePE,
  title={The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer},
  author={J. Hyttel and K. Bogeso and J. Perregaard and C. Sanchez},
  journal={Journal of Neural Transmission / General Section JNT},
  year={2005},
  volume={88},
  pages={157-160}
}
The enantiomers of citalopram and N-demethylcitalopram have been investigated. Based on the inhibition of 5-HT uptake in vitro and the potentiation of 1-5-HTP in vivo the pharmacological activity resides in the (+)-enantiomers (the eutomers) with the 1-(S) absolute configuration. In the 5-HT uptake test eudismic ratios of 167 and 6.6 are obtained for the enantiomers of citalopram and N-demethylcitalopram, respectively. The pharmacological profile of the eutomers of citalopram and N… Expand
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