The pharmacologic treatment of Dravet syndrome

@article{Chiron2011ThePT,
  title={The pharmacologic treatment of Dravet syndrome},
  author={Catherine Chiron and Olivier Dulac},
  journal={Epilepsia},
  year={2011},
  volume={52}
}
Dravet syndrome (DS) is one of the most pharmacoresistant epilepsy syndromes. Valproate is used as a first‐line agent to prevent the recurrence of febrile seizures and oral/nasal/rectal benzodiazepine is used for any long‐lasting seizures, but these agents are most often insufficient. Lamotrigine, carbamazepine, and high doses of intravenous phenobarbital should be avoided because they may worsen seizures. Topiramate, levetiracetam, bromide, and the ketogenic diet may provide substantial… 
Treatment Strategies for Dravet Syndrome
Dravet syndrome (DS) is a medically refractory epilepsy that onsets in the first year of life with prolonged seizures, often triggered by fever. Over time, patients develop other seizure types
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TLDR
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TLDR
A prospective study of patients with Dravet syndrome treated with low-dose fenfluramine and the initial results are promising in terms of reduction of seizure frequency and overall tolerability.
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TLDR
Combination of CLZ with CBD significantly reduced seizure duration compared to the vehicle or CLZ alone, but did not affect seizure severity, indicating potential additive actions ofCLZ and CBD on the duration of seizures.
Of Fish and Men
TLDR
The feasibility of using zebrafish as an animal model of Dravet syndrome to investigate disease mechanisms and the feasibility of HTPS of pharmacologic compounds is investigated.
Clobazam: a newly approved but well-established drug for the treatment of intractable epilepsy syndromes.
TLDR
Historical and recent data are reviewed to help practitioners better understand clobazam's clinical properties and usage and safety profile appears to be similar to that of other benzodiazepines, but with substantially decreased sedation and increased psychomotor performance.
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TLDR
The present study was designed to further investigate the value of stiripentol for children with Dravet syndrome, querying child neurologists who obtained this drug for their U.S. patients over a 7-year period.
Lamotrigine can be beneficial in patients with Dravet syndrome
TLDR
Reintroduction of LTG improved seizure control, suggesting that in some patients with Dravet syndrome, LTG may be beneficial.
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