The pharmacologic basis of the cardiovascular toxicity of minoxidil in the dog.

@article{Mesfin1995ThePB,
  title={The pharmacologic basis of the cardiovascular toxicity of minoxidil in the dog.},
  author={G M Mesfin and Franklin G. Robinson and Michael J. Higgins and W Z Zhong and Donald W. Ducharme},
  journal={Toxicologic pathology},
  year={1995},
  volume={23 4},
  pages={498-506}
}
Minoxidil (MNX), like several other vasoactive drugs, causes cardiovascular toxicity in dogs by undetermined mechanisms. We studied the mechanism of cardiovascular toxicity of MNX [an adenosine triphosphate (ATP)-sensitive potassium channel opener] by blocking its pharmacologic effects with glyburide (an ATP-sensitive potassium channel blocker) in groups of 5 female beagle dogs treated orally for 2 days with 1.0 mg/kg/day of MNX alone or with glyburide given in 5 or 6 divided doses of 300 mg/kg… CONTINUE READING