The pharmacokinetics study of ginkgolide A, B and the effect of food on bioavailability after oral administration of ginkgolide extracts in beagle dogs.

@article{Aa2018ThePS,
  title={The pharmacokinetics study of ginkgolide A, B and the effect of food on bioavailability after oral administration of ginkgolide extracts in beagle dogs.},
  author={Li-xiang Aa and Fei Fei and Zhao-yi Tan and Jiye Aa and Guangji Wang and Changxiao Liu},
  journal={Biomedical chromatography : BMC},
  year={2018},
  volume={32 6},
  pages={
          e4212
        }
}
Ginkgolides are the primarily active components in Ginkgo products that are popular worldwide. However, few studies have evaluated the bioavailability of ginkgolides and the effects of food on it after oral administration of ginkgolides. In this article, pharmacokinetics and absolute bioavailability of the primary components in ginkgolide extracts were evaluated in beagle dogs. For the first time, we showed that the fed dogs had significantly increased area under the concentration-time curve… 
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