The pharmacokinetics of zidovudine administered by continuous infusion in children.

@article{Balis1989ThePO,
  title={The pharmacokinetics of zidovudine administered by continuous infusion in children.},
  author={Frank M Balis and Philip A. Pizzo and Robert F. Murphy and Joyce Eddy and Paul F Jarosinski and Judith Falloon and Samuel E Broder and David G. Poplack},
  journal={Annals of internal medicine},
  year={1989},
  volume={110 4},
  pages={279-85}
}
STUDY OBJECTIVE To define the pharmacokinetics of zidovudine (azidothymidine) in children with human immunodeficiency virus infection. DESIGN Plasma, urine, and cerebrospinal fluid were obtained following a single 80 mg/m2 body surface dose infused over 1 hour (n = 9), and during a continuous infusion of 0.5 (n = 3), 0.9 (n = 8), 1.4 (n = 7), or 1.8 (n = 3) mg/kg body weight per hour. SETTING Outpatient clinic and inpatient ward of the Pediatric Branch of the National Cancer Institute… CONTINUE READING