The pharmacokinetics of remifentanil in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.

@article{Michelsen2001ThePO,
  title={The pharmacokinetics of remifentanil in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.},
  author={Luis G Michelsen and Nick H G Holford and Wei Lu and J. Frank Hoke and Carl C. Hug and J M Bailey},
  journal={Anesthesia and analgesia},
  year={2001},
  volume={93 5},
  pages={1100-5}
}
UNLABELLED Remifentanil is a potent opioid with a short duration of action. It has the potential for large-dose opioid anesthesia without an obligatory prolonged period of mechanical ventilation. However, because of high clearance and rapid tissue distribution, cardiopulmonary bypass (CPB) may influence its pharmacokinetics and alter drug requirements. We administered remifentanil by continuous infusion to 68 patients having coronary artery bypass graft surgery during CPB with hypothermia to… CONTINUE READING

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