The pharmacokinetics of propofol in children using three different data analysis approaches.

@article{Kataria1994ThePO,
  title={The pharmacokinetics of propofol in children using three different data analysis approaches.},
  author={B K Kataria and S A Ved and H F Nicodemus and Gregory R. Hoy and D. Lea and Michel Y Dubois and Jaap W. Mandema and Steven L. Shafer},
  journal={Anesthesiology},
  year={1994},
  volume={80 1},
  pages={104-22}
}
BACKGROUND Accurate dosing of propofol in children requires accurate knowledge of propofol pharmacokinetics in this population. Improvement in pharmacokinetic accuracy may depend on the incorporation of individual patient factors into the pharmacokinetic model or the use of population approaches to estimating the pharmacokinetic parameters. We investigated whether incorporating individual subject covariates (e.g., age, weight, and gender) into the pharmacokinetic model improved the accuracy. We… CONTINUE READING