The pharmacokinetics of pioglitazone in Thai healthy subjects.

  title={The pharmacokinetics of pioglitazone in Thai healthy subjects.},
  author={Supeecha Wittayalertpanya and Sumana Chompootaweep and Nongnuch Thaworn},
  journal={Journal of the Medical Association of Thailand = Chotmaihet thangphaet},
  volume={89 12},
BACKGROUND Pioglitazone is a thiazolidinedione compound used in the treatment of type 2 diabetes, metabolized mainly by CYP2C8 and CYP3A4. Due to genetic polymorphisms in CYP2C8, interethnic variability in pharmacokinetics should be considered. OBJECTIVE To conduct a study on the pharmacokinetics of pioglitazone in Thai subjects. MATERIAL AND METHOD The present study was performed in 24 Thai male healthy subjects. After an overnight fasting, each subject had a single oral dose of 30 mg… CONTINUE READING
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