Corpus ID: 33033454

The pharmacokinetics of nitrendipine. II. Distribution to and elimination from organs and tissues of rats and dogs after single or repeated administration of [14C]nitrendipine.

@article{Krause1988ThePO,
  title={The pharmacokinetics of nitrendipine. II. Distribution to and elimination from organs and tissues of rats and dogs after single or repeated administration of [14C]nitrendipine.},
  author={H. Krause and H. Ahr and H. M. Siefert and W. Steinke and D. Suwelack},
  journal={Arzneimittel-Forschung},
  year={1988},
  volume={38 11},
  pages={
          1599-604
        }
}
  • H. Krause, H. Ahr, +2 authors D. Suwelack
  • Published 1988
  • Medicine
  • Arzneimittel-Forschung
  • [14C]nitrendipine (3-ethyl 5-methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylate, Bay e 5009, Baypress, Bayotensin) was administered to male rats, pregnant and lactating female rats, and female dogs intravenously or orally once as well as to male rats repeatedly over a period of 4 weeks (rat 5 (and 10) mg/kg, dog approximately 3 mg/kg). The distribution of radioactivity (unchanged compound and metabolites) was investigated using whole-body autoradiography as well as… CONTINUE READING
    2 Citations