• Corpus ID: 33033454

The pharmacokinetics of nitrendipine. II. Distribution to and elimination from organs and tissues of rats and dogs after single or repeated administration of [14C]nitrendipine.

@article{Krause1988ThePO,
  title={The pharmacokinetics of nitrendipine. II. Distribution to and elimination from organs and tissues of rats and dogs after single or repeated administration of [14C]nitrendipine.},
  author={H. P. Krause and Hans Juergen Ahr and H. M. Siefert and Wolfram Steinke and Donata Suwelack},
  journal={Arzneimittel-Forschung},
  year={1988},
  volume={38 11},
  pages={
          1599-604
        }
}
[14C]nitrendipine (3-ethyl 5-methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylate, Bay e 5009, Baypress, Bayotensin) was administered to male rats, pregnant and lactating female rats, and female dogs intravenously or orally once as well as to male rats repeatedly over a period of 4 weeks (rat 5 (and 10) mg/kg, dog approximately 3 mg/kg). The distribution of radioactivity (unchanged compound and metabolites) was investigated using whole-body autoradiography as well as… 
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Investigation of the influence of nitrendipine (NIT), a dihydropyridine derived calcium channel antagonist, on polycyclic aromatic hydrocarbon benzo(a)pyrene (BAP)-induced oxidative stress found that NIT pre-treatment protected against increasing TBARS levels in lung and brain tissues, compared to the BAP group.
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