The pharmacokinetics of moxidectin after oral and subcutaneous administration to sheep.

Abstract

The pharmacokinetic parameters of moxidectin were determined in ten sheep following a single subcutaneous or oral drench at a dose of 0.2 mg.kg-1. The plasma kinetics were best fitted by a two-compartment model. Moxidectin was detected in the plasma at the first sampling time (1 h) and thereafter for at least 60 d. The AUC were similar after both treatments… (More)

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