The pharmacokinetics of mianserin in elderly depressed patients.

  title={The pharmacokinetics of mianserin in elderly depressed patients.},
  author={Kay P. Maguire and I M Mcintyre and Trevor R. Norman and Graham Dene Burrows},
  journal={Psychiatry research},
  volume={8 4},
The pharmacokinetics of mianserin were examined in eight elderly depressed patients following a single oral dose of 60 mg. Plasma concentrations were measured by gas chromatography/mass spectrometry and the data analyzed using a two-compartment open model. Mean (+/- SD) estimates were: absorption half-life 0.8 +/- 1.0h, peak concentration 117 +/- 23 micrograms/l, peak time 2.2 +/- 1.3h, distribution half-life 3.4 +/- 1.2h, elimination half-life 33 +/- 15h, apparent volume of distribution 20.2… CONTINUE READING