The pharmacokinetics of melphalan in patients with multiple myeloma: An intravenous/oral study using a conventional dose regimen

@article{Woodhouse1983ThePO,
  title={The pharmacokinetics of melphalan in patients with multiple myeloma: An intravenous/oral study using a conventional dose regimen},
  author={Ken W. Woodhouse and P H Hamilton and Anne L. Lennard and Michael D Rawlins},
  journal={European Journal of Clinical Pharmacology},
  year={1983},
  volume={24},
  pages={283-285}
}
The pharmacokinetics of melphalan have been studied after intravenous and oral dosing (10 mg) in 6 patients with multiple myeloma. After intravenous administration, mean plasma t0.5α was 8.0±2.3 min, t0,5β was 63.3±8.7 min, and total systemic clearance was 510.4±57.9 ml/min. After oral administration, the drug was rapidly absorbed (lagtime=18.4±3.7 min, absorption rate constant=0.0547±0.0166 min−1, Tmax=59.3±6.6 min), but there was considerable variation in its bioavailability (61.5−102.0% mean… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-5 of 5 references

Wolmark N, Fisher ER (1975) L-phenylalamine mustard (L-PAM) in the management of primary breast cancer: a report of early findings

  • B Fisher, P Carhone, +7 authors DL Katrych
  • N Engl J Med
  • 1975
1 Excerpt

Similar Papers

Loading similar papers…