The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital.

@article{Moore2011ThePO,
  title={The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital.},
  author={Sarah Moore and Karen R Mu{\~n}ana and Mark G Papich and Julie A Nettifee-Osborne},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2011},
  volume={34 1},
  pages={
          31-4
        }
}
Levetiracetam (LEV) is a commonly used add-on medication in dogs with refractory epilepsy. The objective of this study was to determine if the pharmacokinetics of LEV are altered by concurrent administration of phenobarbital (PB). Six healthy dogs received a single oral dose of LEV (16.7-27.8 mg/kg). Blood samples were collected at baseline and intermittently for 24 h. The study was repeated after the dogs received oral PB (2.0-3.3 mg/kg) twice daily for 21 days. Plasma LEV levels were… CONTINUE READING
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