The pharmacokinetics of intravenous paracetamol in neonates: size matters most.

@article{Allegaert2011ThePO,
  title={The pharmacokinetics of intravenous paracetamol in neonates: size matters most.},
  author={Karel Allegaert and Greta M Palmer and Brian J Anderson},
  journal={Archives of disease in childhood},
  year={2011},
  volume={96 6},
  pages={575-80}
}
BACKGROUND The aim was to describe intravenous paracetamol pharmacokinetics, determine major covariates and suggest a dosing regimen for (pre)term neonates. METHODS A population pharmacokinetic analysis of 943 paracetamol observations from 158 neonates (27-45 weeks' postmenstrual age (PMA)) was undertaken using non-linear mixed effects models. Data from… CONTINUE READING