The pharmacokinetics of intravenous and oral sulpiride in healthy human subjects

@article{Wiesel2004ThePO,
  title={The pharmacokinetics of intravenous and oral sulpiride in healthy human subjects},
  author={F. Wiesel and G. Alfredsson and M. Ehrnebo and G. Sedvall},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={17},
  pages={385-391}
}
  • F. Wiesel, G. Alfredsson, +1 author G. Sedvall
  • Published 2004
  • Medicine
  • European Journal of Clinical Pharmacology
  • SummaryThe pharmacokinetics of sulpiride was studied in 6 healthy volunteers after intravenous and oral (tablets) administration of 100 mg. An open two- and in two subjects a three-compartment model was applied following intravenous administration. The average total distribution volume during the terminal slope was 2.72±0.66 l/kg and total systemic clearance was 415±84 ml/min. The serum half-life of the terminal slope following intravenous administration averaged 5.3 h (range 3.7–7.1 h… CONTINUE READING

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