The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin

@article{Xenocostas2005ThePO,
  title={The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin},
  author={Anargyros Xenocostas and Wing K. Cheung and Francis Farrell and Cindy Zakszewski and Marian M Kelley and Andrzej Lutynski and Michael A. Crump and Jeffrey Howard Lipton and Thomas L. Kiss and Catherine Y. Lau and Hans A. Messner},
  journal={European Journal of Clinical Pharmacology},
  year={2005},
  volume={61},
  pages={189-195}
}
Erythropoietin (EPO) was originally described as a regulator of erythropoiesis. Recently, synthesis of EPO and expression of the EPO receptor (EPO-R) have been reported for the central nervous system (CNS). The potential use of EPO to prevent or reduce CNS injury and the paucity of information regarding its entry into the human CNS led us to examine the pharmacokinetics (PK) of recombinant human EPO (r-HuEPO) in the serum and cerebrospinal fluid (CSF). Four patients with Ommaya reservoirs were… CONTINUE READING