The pharmacokinetics of cyclosporine. I. Single dose and constant rate infusion studies in the rabbit.

@article{Awni1985ThePO,
  title={The pharmacokinetics of cyclosporine. I. Single dose and constant rate infusion studies in the rabbit.},
  author={Walid M. Awni and Ronald J. Sawchuk},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1985},
  volume={13 2},
  pages={127-32}
}
A two-part study was conducted to characterize the pharmacokinetics of cyclosporine in rabbits. First, cyclosporine was given iv as boluses to nine rabbits in doses of 5, 10, and 20 mg/kg. At each dose level, three rabbits were used. Analysis of blood samples collected was performed by HPLC. The data indicate an increase in the half-life of the terminal phase (255 to 550 min), and in the volume of distribution at steady state (3.16 to 7.82 liters/kg) with increasing dose (5 to 20 mg/kg… CONTINUE READING