The pharmacokinetics of clotiazepam after oral and sublingual administration to volunteers


We have studied the single dose pharmacokinetics of 5 mg clotiazepam drops, oral tablets, and sublingual tablets in a cross-over study in 6 healthy volunteers (median age 28 years). The formulations had similar systemic availability. Compared with oral tablets the sublingual route gave a lower peak concentration and a delayed peak time, while drops gave a… (More)
DOI: 10.1007/BF00562556


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