The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women.

@article{Setchell2009ThePO,
  title={The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women.},
  author={Kenneth D. R. Setchell and Xueheng Zhao and Susan Elizabeth Shoaf and Karen D Ragland},
  journal={The Journal of nutrition},
  year={2009},
  volume={139 11},
  pages={2037-43}
}
The soy isoflavone metabolite, S-(-)equol, has selective affinity for estrogen receptor (ER)beta and also antagonizes in vivo the action of dihydrotestosterone. It is therefore of interest as a potential new therapeutic agent in hormone-dependent conditions and is under development as a nutraceutical. Our objective in this study was to define the pharmacokinetics of natural S-(-)equol after administration of SE5-OH, a newly developed S-(-)equol supplement made by incubation of the equol… CONTINUE READING

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