The pharmacokinetics and pharmacodynamics of bumetanide in normal subjects

@article{Marcantonio1982ThePA,
  title={The pharmacokinetics and pharmacodynamics of bumetanide in normal subjects},
  author={Laurence A. Marcantonio and W. Auld and Graham G. Skellern and Christine A. Howes and W. Ronald Murdoch and Rameshwar Purohit},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1982},
  volume={10},
  pages={393-409}
}
The pharmacokinetics and pharmacodynamics of bumetanide (1 mg) administered either orally or intravenously were studied in a group of normal subjects using high-pressure liquid chromatography. A two-compartment model adequately fitted the intravenous data. Renal clearance (85 ml min−1 contributed 65% to the total elimination of bumetanide irrespective of… CONTINUE READING