The pharmacokinetics and pharmacodynamics of rapid-acting insulin analogues and their clinical consequences.

@article{Home2012ThePA,
  title={The pharmacokinetics and pharmacodynamics of rapid-acting insulin analogues and their clinical consequences.},
  author={Philip D Home},
  journal={Diabetes, obesity & metabolism},
  year={2012},
  volume={14 9},
  pages={780-8}
}
Postprandial glucose excursions can inhibit achievement of good glycaemic control, and possibly have a specific effect on the risk of vascular comorbidities. Rapid-acting analogues control these excursions better than human insulin because their pharmacokinetic/pharmacodynamic (PK/PD) profile is closer to that of meal-time endogenous insulin secretion. Review of the findings of PK/PD studies and clinical trials suggests that the three marketed rapid-acting analogues--insulin lispro, insulin… CONTINUE READING
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