The pharmacokinetics and pharmacodynamics of agents proven to raise high-density lipoprotein cholesterol.

@article{Piepho2000ThePA,
  title={The pharmacokinetics and pharmacodynamics of agents proven to raise high-density lipoprotein cholesterol.},
  author={Robert Walter Piepho},
  journal={The American journal of cardiology},
  year={2000},
  volume={86 12A},
  pages={35L-40L}
}
Bile acid sequestrants, fibric acid derivatives (fibrates), hydroxy-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors ("statins"), and niacin are able to increase HDL-C serum concentrations to varying degrees. Bile acid sequestrants are the least effective, whereas niacin is the most powerful agent for increasing HDL-C levels. Because of 2 alternate metabolic pathways of niacin breakdown, flushing or hepatotoxicity can occur in patients taking niacin. These effects can be mediated in a… CONTINUE READING

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