The pharmacokinetics and pharmacodynamics of medifoxamine after oral administration in healthy elderly volunteers

  title={The pharmacokinetics and pharmacodynamics of medifoxamine after oral administration in healthy elderly volunteers},
  author={Nicola Gainsborough and M L Nelson and Vivienne Maskrey and Cameron G. Swift and Stephen H. D. Jackson},
  journal={European Journal of Clinical Pharmacology},
The pharmacokinetics and psychomotor effects of medifoxamine, a 5 HT reuptake inhibitory antidepressant, were studied in healthy elderly volunteers after single and multiple dosing.The elimination half life (t1/2z) after single doses of 300 mg was 2.8 h — almost identical to that found in young volunteers. After seven days of dosing at 100 mg three times daily the mean corrected AUC after 300 mg significantly increased from 1.04 to 1.34 mg.h.l−1 and t1/2z increased to 4.0 h (NS).There were no… 


Medifoxamine: Oral tolerance and pharmacokinetic study in healthy human volunteers
It was found that medifoxamine underwent rapid absorption and peak plasma concentrations were achieved about 1.0 h after administration, and the elimination profile was biphasic with a mean terminal half life less than 3 hours.
Absolute bioavailability and pharmacokinetics of medifoxamine in healthy humans.
A biexponential decline of serum medifoxamine concentration was observed after intravenous administration in all subjects and similar terminal elimination half-lives were observed following both routes, indicating that oral absorption is not rate-limiting.
Tolerability and kinetics of intravenous medifoxamine in healthy volunteers.
One subject had high serum concentrations and low clearance when compared with the other subjects, which may have been due to genetic differences in drug metabolism, as this subject was found to be a poor metabolizer of debrisoquine.
A psychopharmacological study to assess anti‐muscarinic and central nervous effects of medifoxamine in normal volunteers
Ten volunteers received single oral doses of medifoxamine 50 and 100 mg, atropine 1 mg, amitriptyline 50 mg or placebo in random order based on a Latin square design under double‐blind conditions to investigate the effects of anti‐muscarinic and central nervous activity on sedation and alertness.
A 1,4-benzodiazepine, temazepam (K 3917), its effect on some psychological parameters of sleep and behaviour.
Temazepam showed very much the same effects as they are known from conventional 1,4-benzodiazepines except for its lack of impairment in early morning behavior following night time medication.
Computerised psychomotor performance testing: a comparative study of the single dose pharmacodynamics of minaprine and amitriptyline in young and elderly subjects.
Analysis of variance showed that continuous attention test (CAT), critical flicker fusion threshold (CFFT), decision making test (DMT) and paired word association (PWA) were significantly impaired with amitriptyline compared with minaprine and placebo.
Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations
Plasma concentrations of ethoxybenzamide, sulfisoxazole, bishydroxycoumarin, and diazepam measured following bolus intravenous injection were used as clinical examples for this method.
Critical flicker frequency and centrally-acting drugs.
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    The British journal of ophthalmology
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Cff has been used as a test of central nervous activity in response to drugs for many years and has a number of determinants including the luminance,Wave-length, wave-form, and light-dark ratio of the stimulating light, the area, position, andLight-adapted state of the retina illuminated, the duration of exposure, and the size of the pupil.
1990b) Medifoxamine: oral tolerance and pharmacokinetic study in healthy human volunteers
  • Eur J Clin Pharmaco139:169-171
  • 1990