The pharmacokinetics and pharmacodynamics of medifoxamine after oral administration in healthy elderly volunteers

@article{Gainsborough2004ThePA,
  title={The pharmacokinetics and pharmacodynamics of medifoxamine after oral administration in healthy elderly volunteers},
  author={N. Gainsborough and M. Nelson and V. Maskrey and C. Swift and S. H. D. Jackson},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={46},
  pages={163-166}
}
  • N. Gainsborough, M. Nelson, +2 authors S. H. D. Jackson
  • Published 2004
  • Medicine
  • European Journal of Clinical Pharmacology
  • The pharmacokinetics and psychomotor effects of medifoxamine, a 5 HT reuptake inhibitory antidepressant, were studied in healthy elderly volunteers after single and multiple dosing.The elimination half life (t1/2z) after single doses of 300 mg was 2.8 h — almost identical to that found in young volunteers. After seven days of dosing at 100 mg three times daily the mean corrected AUC after 300 mg significantly increased from 1.04 to 1.34 mg.h.l−1 and t1/2z increased to 4.0 h (NS).There were no… CONTINUE READING

    Tables and Topics from this paper

    References

    SHOWING 1-10 OF 18 REFERENCES
    Medifoxamine: Oral tolerance and pharmacokinetic study in healthy human volunteers
    • 3
    Absolute bioavailability and pharmacokinetics of medifoxamine in healthy humans.
    • 3
    Tolerability and kinetics of intravenous medifoxamine in healthy volunteers.
    • 2
    Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations
    • 1,050
    Critical flicker frequency and centrally-acting drugs.
    • P. Turner
    • Medicine
    • The British journal of ophthalmology
    • 1968
    • 64
    • PDF
    1990b) Medifoxamine: oral tolerance and pharmacokinetic study in healthy human volunteers
    • Eur J Clin Pharmaco139:169-171
    • 1990
    A continuous attention test for the assessment of the acute behavioral effects of drugs.
    • B. Tiplady
    • Psychology, Medicine
    • Psychopharmacology bulletin
    • 1988
    • 29