The pharmacokinetics and pharmacodynamics of a new sustained-release leuprolide acetate depot compared to market references.

@article{Leitner2008ThePA,
  title={The pharmacokinetics and pharmacodynamics of a new sustained-release leuprolide acetate depot compared to market references.},
  author={Judith Maria Leitner and Florian B. Mayr and Alexander O. Spiel and Christa Firbas and Claudio Savulsky and Ricard Mis and Mario Ermanno Corrado and Bernd Jilma},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2008},
  volume={46 8},
  pages={407-14}
}
OBJECTIVE The aim of this study was to compare the efficacy of Lutrate 3.75 and 7.5 mg depot to marketed references Lucrin 3.75 mg and Procrin 7.5 mg depot. METHODS 20 healthy male volunteers were randomly assigned to receive 1 of 4 active single dose treatments in this double-blind, parallel-group pilot study. Leuprolide acetate and testosterone levels were quantified by radioimmunoassays. RESULTS The pharmacokinetic profile of leuprolide could be well-described by a 4-step release curve… CONTINUE READING