The pharmacokinetics and metabolism of ifosfamide during bolus and infusional administration: a randomized cross-over study.

@article{Singer1998ThePA,
  title={The pharmacokinetics and metabolism of ifosfamide during bolus and infusional administration: a randomized cross-over study.},
  author={J. M. Julio da Motta Singer and Janet M. Hartley and Claudia Brennan and Paul W. Nicholson and Robert L. Souhami},
  journal={British Journal of Cancer},
  year={1998},
  volume={77},
  pages={978 - 984}
}
In a randomized cross-over trial, 11 patients received ifosfamide (IFOS) in 21-day cycles, which alternated between 3 g m(-2) x (2 or 3) days given as a 1-h bolus doses, or the same total dose as a continuous infusion. Patients who received four or more cycles also alternated between two cycles on dexamethasone 4 mg 8 hourly for 3 days starting 8 h before IFOS, and two cycles off dexamethasone. A total of 34 patient cycles were studied and serum and urinary levels of IFOS, 2… CONTINUE READING
9 Citations
28 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Identification of the major human hepatic cytochrome P 450 involved in activation and n - dechloroethylation of Ifosfamide

  • D Walker, Flinois J-P, +8 authors Idle
  • Biochem Pharmacol
  • 1994
1 Excerpt

Similar Papers

Loading similar papers…