The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (PC-SOD) in man.

@article{Broeyer2008ThePA,
  title={The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (PC-SOD) in man.},
  author={F. J. F. Broeyer and Benien E van Aken and Jun Suzuki and Michiel J. B. Kemme and Hendrik C Schoemaker and Adam F Cohen and Yutaka Mizushima and Jacobus Burggraaf},
  journal={British journal of clinical pharmacology},
  year={2008},
  volume={65 1},
  pages={22-9}
}
AIM To study the pharmacokinetics (PK), safety and tolerability of single rising doses up to 80 mg of superoxide dismutase covalently linked to lecithin (PC-SOD) in healthy White volunteers. METHODS This double-blind, placebo-controlled, four-period cross-over study was performed in eight healthy volunteers (four male/four female). Three doses of PC-SOD (20, 40 and 80 mg) and placebo were administered intravenously in randomized order. Serum and urinary PC-SOD concentrations were measured… CONTINUE READING