The pharmacokinetics and analgesic efficacy of larger dose rectal acetaminophen (40 mg/kg) in adults: a double-blinded, randomized study.

@article{Beck2000ThePA,
  title={The pharmacokinetics and analgesic efficacy of larger dose rectal acetaminophen (40 mg/kg) in adults: a double-blinded, randomized study.},
  author={Dieter H. Beck and Michael R Schenk and Katrin Hagemann and Ulrich R. Doepfmer and Wolfgang J. Kox},
  journal={Anesthesia and analgesia},
  year={2000},
  volume={90 2},
  pages={
          431-6
        }
}
UNLABELLED Analgesic acetaminophen plasma concentrations are not known. We investigated in a randomized, double-blinded study the pharmacokinetics and analgesic efficacy of small- (AS; 20 mg. kg(-1)) and larger- (AL; 40 mg/kg) dose rectal acetaminophen and compared it with the combination (C) of rectal diclofenac (100 mg) and acetaminophen (20 mg/kg) in 65 women undergoing hysterectomy. Suppositories were administered after the induction of a standardized general anesthesia. Pain (measured by… CONTINUE READING
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