The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics.

@article{Toutain2002ThePA,
  title={The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics.},
  author={P. L. Toutain and J{\'e}r{\^o}me R E Del Castillo and Alain Bousquet-M{\'e}lou},
  journal={Research in veterinary science},
  year={2002},
  volume={73 2},
  pages={105-14}
}
Pharmacokinetic-pharmacodynamic (PK/PD) surrogate indices (AUIC, AUC/MIC, C(max)/MIC, T>MIC) for measuring antibiotic efficacy are presented and reviewed. As clinical trials are not sufficiently sensitive to establish a dosage regimen which guarantees total bacteriological cure (Pollyanna phenomenon), PK/PD indexes have been proposed from in vitro, ex vivo, and in vivo infection models and subsequently validated in retrospective or prospective human clinical trials. The target value for time… CONTINUE READING

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