The pharmacokinetic interaction between isoniazid/pyrazinamide and TMC207, an investigational antimycobacterial agent

@inproceedings{Heeswijk2007ThePI,
  title={The pharmacokinetic interaction between isoniazid/pyrazinamide and TMC207, an investigational antimycobacterial agent},
  author={Remko van Heeswijk and Ruth Lachaert and Lorant Leopold and Karel De Beule and David F. McNeeley and Richard M. W. Hoetelmans},
  year={2007}
}
TMC207 was administered at a dose of 400 mg q.d. Isoniazid/pyrazinamide (H/Z) were simultaneously co-administered at a dose of 300/2000 mg q.d. All drugs were administered with food Bioanalysis of all drugs as well as M2, an active metabolite of TMC207, was carried out by validated LC-MS/MS methods Non-compartmental PK analysis was performed (Cmax, Cmin, C0h and AUC24h) Statistical analysis of pharmacokinetic parameters was performed by linear mixed effects modeling (LSM ratio and 90… CONTINUE READING

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