The pharmacokinetic and metabolic profile of olmesartan medoxomil limits the risk of clinically relevant drug interaction.

@article{Laeis2001ThePA,
  title={The pharmacokinetic and metabolic profile of olmesartan medoxomil limits the risk of clinically relevant drug interaction.},
  author={Petra Laeis and K. P{\"u}chler and Wilhelm Kirch},
  journal={Journal of hypertension. Supplement : official journal of the International Society of Hypertension},
  year={2001},
  volume={19 1},
  pages={S21-32}
}
Orally administered olmesartan medoxomil was rapidly absorbed from the gastrointestinal tract and converted during absorption to olmesartan, the pharmacologically active metabolite that was subsequently excreted without further metabolism. The medoxomil moiety was released as diacetyl that was rapidly cleared by further metabolism and excretion. Peak plasma concentrations of olmesartan occurred 1-3 h after administration, after which concentrations decreased quickly. The elimination half-life… CONTINUE READING

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