The pharmacogenetics of analgesia

  title={The pharmacogenetics of analgesia},
  author={Ulrike M Stamer and Frank St{\"u}ber},
  journal={Expert opinion on pharmacotherapy},
  volume={8 14},
Genomic variations influencing response to pharmacotherapy of pain are under investigation. Candidate genes such as (opioid)-receptors, transporters and other molecules important for pharmacotherapy are discussed. Drug metabolising enzymes represent a further major target of ongoing research in order to identify associations between an individual's genetic profile and drug response (pharmacogenetics). Polymorphisms of the cytochrome P450 enzymes influence analgesic efficacy of codeine, tramadol… CONTINUE READING
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