The pharmacodynamic effect of a remifentanil bolus on ventilatory control.

@article{Babenco2000ThePE,
  title={The pharmacodynamic effect of a remifentanil bolus on ventilatory control.},
  author={H D Babenco and Pascale Conard and Jeffrey B. Gross},
  journal={Anesthesiology},
  year={2000},
  volume={92 2},
  pages={393-8}
}
BACKGROUND In doses typically administered during conscious sedation, remifentanil may be associated with ventilatory depression. However, the time course of ventilatory depression after an initial dose of remifentanil has not been determined previously. METHODS In eight healthy volunteers, the authors determined the time course of the ventilatory response to carbon dioxide using the dual isohypercapnic technique. Subjects breathed via mask from a to-and-fro circuit with variable carbon… CONTINUE READING