The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa.

@article{Cavaliersmith2002ThePO,
  title={The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa.},
  author={T Cavalier-smith},
  journal={International journal of systematic and evolutionary microbiology},
  year={2002},
  volume={52 Pt 2},
  pages={
          297-354
        }
}
  • T. Cavalier-smith
  • Published 1 March 2002
  • Biology, Medicine
  • International journal of systematic and evolutionary microbiology
Eukaryotes and archaebacteria form the clade neomura and are sisters, as shown decisively by genes fragmented only in archaebacteria and by many sequence trees. This sisterhood refutes all theories that eukaryotes originated by merging an archaebacterium and an alpha-proteobacterium, which also fail to account for numerous features shared specifically by eukaryotes and actinobacteria. I revise the phagotrophy theory of eukaryote origins by arguing that the essentially autogenous origins of most… 
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It is shown that eukaryotes and archaebacteria are sisters, forming the clade neomura that evolved ~1.2 Gy ago from a posibacterium, whose DNA segregation and cell division were destabilized by murein wall loss and rescued by the evolving novel neomuran endoskeleton, histones, cytokinesis, and glycoproteins.
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  • E. Koonin
  • Biology, Medicine
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2015
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Comparative genomic analysis clearly shows that the last eukaryotic common ancestor (LECA) possessed most of the signature complex features of modern eUKaryotic cells, in particular the mitochondria, the endomembrane system including the nucleus, an advanced cytoskeleton and the ubiquitin network.
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  • V. Emelyanov
  • Biology, Medicine
    European journal of biochemistry
  • 2003
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Phylogenetic evidence is presented that primitively amitochondriate eukaryotes containing the nucleus, cytoskeleton, and endomembrane system may have never existed, and sequential, or converging, global events could fill the gap between prokaryotes and eUKaryotes known as major evolutionary discontinuity.
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The latest striking discovery made by deep metagenomic sequencing vindicates the hypothesis that in phylogenetic trees eukaryotes fall within a newly identified archaeal group, the Lokiarchaeota, which combine several eukARYotic signatures previously identified in different archaea.
The neomuran origin of archaebacteria, the negibacterial root of the universal tree and bacterial megaclassification.
  • T. Cavalier-smith
  • Biology, Medicine
    International journal of systematic and evolutionary microbiology
  • 2002
TLDR
The origin from a drastically altered actinobacterium of neomura, and the immediately subsequent simultaneous origins of archaebacteria and eukaryotes, are the most extreme and important cases of quantum evolution since cells began.
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TLDR
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Multiple late origins of phagocytosis could help explain why many of the ecological and evolutionary innovations of the Neoproterozoic Era happened when they did.
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  • Biology, Medicine
    International journal of systematic and evolutionary microbiology
  • 2002
TLDR
The origin from a drastically altered actinobacterium of neomura, and the immediately subsequent simultaneous origins of archaebacteria and eukaryotes, are the most extreme and important cases of quantum evolution since cells began.
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