The phagocytes: neutrophils and monocytes.

@article{Dale2008ThePN,
  title={The phagocytes: neutrophils and monocytes.},
  author={David C Dale and Laurence A. Boxer and W Conrad Liles},
  journal={Blood},
  year={2008},
  volume={112 4},
  pages={
          935-45
        }
}
The production and deployment of phagocytes are central functions of the hematopoietic system. In the 1950s, radioisotopic studies demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue macrophages, histiocytes, and dendritic cells. Subsequently, the discovery of the colony-stimulating factors greatly improved understanding the regulation of phagocyte production. The… 

Figures from this paper

Neutrophils and Macrophages: the Main Partners of Phagocyte Cell Systems
TLDR
The justifications behind the inclusion of neutrophils in a phagocyte system are expanded and the MYPS are further characterized as a group of dedicated phagocytic cells that function in an interacting and cooperative way in the host defense against microbial infection.
Dangerous connections: neutrophils and the phagocytic clearance of activated platelets
TLDR
A bona-fide synapse assembles as a consequence of the interaction between P-selectin and its counter-receptor on neutrophils, with clustering of activated β2 integrins into membrane microdomains and reorganization of cytoskeleton components that control cell motility and phagocytosis.
Chemokine Receptors and Phagocyte Biology in Zebrafish
TLDR
This review discusses how the zebrafish model has furthered the understanding of the role of two main classes of chemokine receptors, the CC and CXC subtypes, in phagocyte biology and addresses the roles of the receptors in the migratory properties of phagocytes in zebra fish models for cancer, infectious disease, and inflammation.
When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system
TLDR
Data is highlighted suggesting the perspective that the combination of overlapping and complementary characteristics of the two professional phagocytes promotes their cooperative participation as effectors and modulators in innate immunity against infection and as orchestrators of adaptive immunity.
Neutrophil biology and the next generation of myeloid growth factors.
  • D. Dale
  • Biology, Medicine
    Journal of the National Comprehensive Cancer Network : JNCCN
  • 2009
TLDR
Recent research shows that hematopoietic progenitor cells can be mobilized with a chemokine receptor antagonist, chemotherapy, G-CSF, and granulocyte macrophage colony-stimulating factor, offering opportunities for the development of alternative drugs and treatments.
Phagocytosis: Hungry, Hungry Cells.
TLDR
Past and recent discoveries are reviewed that highlight how phagocytes recognize target particles, key signals that emanate after phagocyte-particle engagement, and how these signals help modulate actin-dependent remodeling of the plasma membrane that culminates in the release of the phagosome.
Diversity and environmental adaptation of phagocytic cell metabolism
TLDR
Current understanding of metabolism in phagocytic cells is reviewed to highlight the need for additional studies that hopefully enable improved cell‐based strategies for counteracting cancer and other diseases.
The Role and Function of Fcγ Receptors on Myeloid Cells.
TLDR
This chapter discusses the mechanisms that regulate Fc domain binding to the various types of Fc receptors and provides an overview of the astonishing diversity of effector functions that are mediated through Fc-FcR interactions on myeloid cells.
...
...

References

SHOWING 1-10 OF 194 REFERENCES
Myeloperoxidase: friend and foe
TLDR
It is concluded that the MPO system plays an important role in the microbicidal activity of phagocytes and the role of theMPO system in tissue injury.
DIFFERENTIATION OF MONOCYTES : Origin, Nature, and Fate of Their Azurophil Granules
TLDR
It appears that the monocyte produces two types of primary lysosomes during different phases of its life cycle—azurophil granules made by developing monocytes in bone marrow or blood, and coated vesicles made by macrophages in tissues and body cavities.
THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY
TLDR
From data, it appears that the conversion of a monocyte-like cell to a mature macrophage is accompanied by the formation of increased numbers of lysosome-like cytoplasmic organelles.
Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases
TLDR
Key structural and functional features of the neutrophil NADPH oxidase and its protein components are described, including a consideration of transcriptional and post‐translational regulatory features.
Neutrophil apoptosis pathways and their modifications in inflammation
  • H. Simon
  • Biology, Medicine
    Immunological reviews
  • 2003
TLDR
This review focuses on recently published work regarding signaling pathways that regulate neutrophil apoptosis and can be accelerated both in the presence and in the absence of survival factors by activation of distinct members of the tumor necrosis factor/nerve growth factor receptor family.
The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis.
  • I. SabroeS. DowerM. Whyte
  • Biology, Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
TLDR
It is suggested that activation of neutrophils by TLRs is highly regulated, permitting acute neutrophil antimicrobial responses to TLR activation while providing a "brake" on inflammation by requiring the presence of mononuclear cells to significantly extend neutrophIL survival.
THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW
TLDR
The findings indicate that the situation is basically the same as described previously in the rabbit, insofar as the origin, enzymic activity, and persistence in the mature cell of the two types of granules are concerned.
Regulation of the immune response--role of the macrophage.
  • A. Rosenthal
  • Biology, Medicine
    The New England journal of medicine
  • 1980
MACROPHAGES facilitate a variety of thymus-dependent immunologic phenomena in human beings and laboratory animals; thus, these cells are essential for the development of cellular and humoral
Antibiotic proteins of human neutrophils.
  • J. Spitznagel
  • Biology, Medicine
    The Journal of clinical investigation
  • 1990
TLDR
One aspect of research on oxygen-independent mechanisms, the antibiotic proteins of human neutrophils, comprises at least three structurally different families that share the capacity to kill bacteria independent of oxygen and evidently, contrary to Metchnikov's conjecture, to do so independent of enzymic action.
...
...