The phagocytes: neutrophils and monocytes.

@article{Dale2008ThePN,
  title={The phagocytes: neutrophils and monocytes.},
  author={David C Dale and Laurence A. Boxer and W Conrad Liles},
  journal={Blood},
  year={2008},
  volume={112 4},
  pages={
          935-45
        }
}
The production and deployment of phagocytes are central functions of the hematopoietic system. In the 1950s, radioisotopic studies demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue macrophages, histiocytes, and dendritic cells. Subsequently, the discovery of the colony-stimulating factors greatly improved understanding the regulation of phagocyte production. The… Expand
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References

SHOWING 1-10 OF 191 REFERENCES
Myeloperoxidase: friend and foe
  • S. Klebanoff
  • Biology, Medicine
  • Journal of leukocyte biology
  • 2005
TLDR
It is concluded that the MPO system plays an important role in the microbicidal activity of phagocytes and the role of theMPO system in tissue injury. Expand
Novel cytochrome b system in phagocytic vacuoles of human granulocytes
TLDR
A cytochrome b system which becomes incorporated into the phagocytic vacuoles of human neutrophils, and abnormalities in patients with CGD implicate it as an essential component of the microbicidal oxidase system. Expand
THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES
TLDR
It was concluded that the rapidly dividing mononuclear phagocytes of the bone marrow, called promonocytes, are the progenitor cells of the monocytes and give rise to peritoneal macrophages. Expand
DIFFERENTIATION OF MONOCYTES : Origin, Nature, and Fate of Their Azurophil Granules
TLDR
It appears that the monocyte produces two types of primary lysosomes during different phases of its life cycle—azurophil granules made by developing monocytes in bone marrow or blood, and coated vesicles made by macrophages in tissues and body cavities. Expand
THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY
TLDR
From data, it appears that the conversion of a monocyte-like cell to a mature macrophage is accompanied by the formation of increased numbers of lysosome-like cytoplasmic organelles. Expand
The Role of the Macrophage in Apoptosis: Hunter, Gatherer, and Regulator
TLDR
It is possible that certain malignant tumor cells co-opt the mechanisms for apoptotic cell clearance to avoid immune surveillance by subverting macrophage and dendritic cell responses. Expand
Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases
TLDR
Key structural and functional features of the neutrophil NADPH oxidase and its protein components are described, including a consideration of transcriptional and post‐translational regulatory features. Expand
Neutrophil apoptosis pathways and their modifications in inflammation
  • H. Simon
  • Biology, Medicine
  • Immunological reviews
  • 2003
TLDR
This review focuses on recently published work regarding signaling pathways that regulate neutrophil apoptosis and can be accelerated both in the presence and in the absence of survival factors by activation of distinct members of the tumor necrosis factor/nerve growth factor receptor family. Expand
The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis.
  • I. Sabroe, S. Dower, M. Whyte
  • Biology, Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
TLDR
It is suggested that activation of neutrophils by TLRs is highly regulated, permitting acute neutrophil antimicrobial responses to TLR activation while providing a "brake" on inflammation by requiring the presence of mononuclear cells to significantly extend neutrophIL survival. Expand
THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW
TLDR
The findings indicate that the situation is basically the same as described previously in the rabbit, insofar as the origin, enzymic activity, and persistence in the mature cell of the two types of granules are concerned. Expand
...
1
2
3
4
5
...