The phage shock protein PspA facilitates divalent metal transport and is required for virulence of Salmonella enterica sv. Typhimurium.

@article{Karlinsey2010ThePS,
  title={The phage shock protein PspA facilitates divalent metal transport and is required for virulence of Salmonella enterica sv. Typhimurium.},
  author={Joyce E. Karlinsey and Michael E. Maguire and Lynne A Becker and Marie-Laure V. Crouch and Ferric C Fang},
  journal={Molecular microbiology},
  year={2010},
  volume={78 3},
  pages={669-85}
}
The phage shock protein (Psp) system is induced by extracytoplasmic stress and thought to be important for the maintenance of proton motive force. We investigated the contribution of PspA to Salmonella virulence. A pspA deletion mutation significantly attenuates the virulence of Salmonella enterica serovar Typhimurium following intraperitoneal inoculation of C3H/HeN (Ity(r) ) mice. PspA was found to be specifically required for virulence in mice expressing the natural resistance-associated… CONTINUE READING

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